Search Results
The Molecular Basis of Schizophrenia and Bipolar Disorder (X1)
06-Mar-2009 -
10-Mar-2009
Keystone
Colorado
USA
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"This meeting brings together experts in a range of disciplines, including genetics, neurobiology, cell and developmental biology, psychiatry, and chemical biology to discuss the molecular bases of bipolar disorder and schizophrenia. The time is opportune, since new methods in genetics are identifying plausible candidate genes, which can be studied by sophisticated techniques of cell biology and neuroscience, in both laboratory and clinical settings. Bipolar disorder and schizophrenia are severe psychiatric syndromes characterized by mood and cognitive disorders and psychosis. Both genetic and environmental factors are believed to contribute. New findings in genetics and neuroscience will likely help redefine the phenotypes and make possible the development of new therapeutic targets. Among the topics to be explored include emerging data from genetics implicating new genes and genetic variation in disease; the current status of the epidemiology, including environmental factors, and boundaries of the disorders; the genetics and neurobiology of several current candidate genes and pathways; and the relevance of advances in neurogenesis, fast-evolving brain genes, and cerebral circuitry development. Finally, prospects for new approaches to therapeutics will be covered. The overall goal of this meeting is to integrate molecular studies across basic and clinical disciplines and facilitate the development of new approaches. "
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Registration Deadline: 06-Nov-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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Regulatory T Cells (C5)
01-Mar-2009 -
06-Mar-2009
Keystone
Colorado
USA
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"Over the past few years Regulatory T cells have taken center stage in the field of immunoregulation. Several types of regulatory T cell have been described on the basis of their origin, generation and mechanism of action, with two main subsets identified: naturally occurring FOXP3+ regulatory T cells and inducible regulatory T cells. All types of regulatory T cell, by virtue of their capacity to control the intensity of effector responses, have been shown to play a major role in the control of immune responses at large. This meeting will highlight recent developments in our understanding of the molecular basis for the differentiation of naturally occurring or inducible regulatory T cells. The second goal is to discuss information on the targets, mechanism of action, recruitment and homeostasis of regulatory T cells. The third goal is to discuss recent advances in our understanding of the conditions favoring the emergence and regulation of these populations and to discuss how these findings are translated in clinical trials. "
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Registration Deadline: 03-Nov-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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B cells in context (C3)
24-Feb-2009 -
01-Mar-2009
Taos
New Mexico
USA
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"B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools. Failures in these processes can lead to autoimmune disease and lymphoid malignancy. These events involve highly choreographed cell-cell interactions and migratory behaviors. The goal of this meeting will be to ask how the various B cell microenvironments regulate the molecular events that determine B cell fate and function, and to explore how manipulation of the microenvironment can impact the immune response, autoimmunity, transformation and vaccine development. "
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Registration Deadline: 22-Oct-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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Chromatin Dynamics and Higher Order Organization (C4)
25-Feb-2009 -
02-Mar-2009
Coeur d'Alene
Idaho
USA
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"Research in the past decade has revealed the intimate link of chromatin structure at the levels of histone modifications and nucleosome remodeling to nuclear functions, especially gene regulation. Yet the molecular mechanisms of higher orders of chromatin organization beyond the nucleosomal array remain largely obscure. Evidence is emerging that chromatin folding and large-scale chromatin interactions, including trans-interactions between chromosomes, play an important role in gene regulation, recombination, and other nuclear processes. Chromatin looping may be a key component of regulatory mechanisms. New roles of non-coding RNAs in regulating chromatin function are also uprising. Furthermore, functional compartments, such as transcription factories, replication factories, and polycomb bodies have been suggested to organize the nucleus. This meeting will focus on recent breakthroughs in our understanding of the mechanisms that govern dynamics of higher-order chromatin architecture in order to gain important insights into gene regulation and disregulation, DNA repair, normal development, stem cell function, epigenetic inheritance and diseases such as cancer. "
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Registration Deadline: 27-Oct-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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Chemical Senses: Receptors and Circuits (C7)
15-Mar-2009 -
19-Mar-2009
Tahoe City
California
USA
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"The goal of this Keystone meeting is to bring together both pioneers and newcomers to the neurobiology of the chemical senses to discuss the development and function of neuronal circuits that underlie the perception of odorants, tastants, and pheromones. In the decade since the identification of molecular receptors for chemosensory stimuli, the field is increasingly moving toward questions of how sensory circuits are assembled during development and how they function in mediating chemosensory perception. Researchers are elucidating the molecules and mechanisms that pattern connections from the periphery to the brain. Using electrophysiological and imaging techniques, information processing is being studied mostly at the periphery. However, there is little information about how information is propagated from lower pathways to the cortex (or equivalent) and other higher brain regions. This meeting will highlight recent results using developmental, electrophysiological, functional imaging, and behavioral approaches to elucidate how chemosensory signals are processed in invertebrate and vertebrate model systems, ranging from nematode, fruit fly, zebrafish, mouse, rat, non-human primate to human. "
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Registration Deadline: 17-Nov-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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"Epigenetics, Development and Human Disease"
05-Jan-2009 -
10-Jan-2009
Breckenridge
Colorado
USA
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"This meeting aims to provide a stimulating forum for exploring the epigenetic control of genome function illustrated through the regulation of a variety of biological processes in a range of model organisms. The role of factors influencing chromatin organization and chromosome architecture, and the dynamic changes in epigenetic state that regulate development, are two well-established but fast-moving areas that will be covered. The dynamic nature of epigenetic states renders them both adaptable and vulnerable; this will be explored in sessions considering the influence of the environment on epigenetic control, and the causes and consequences of epigenetic change in disease. We anticipate that the data presented will allow evolutionary insights and functional comparison of epigenetic mechanisms in different organisms and systems, resulting in the integration of ideas to generate new concepts and a deeper understanding in this field. "
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Registration Deadline: 15-Sep-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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Angiogensis and Lymphangiogensis in Cancer
06-Jan-2009 -
11-Jan-2009
Big Sky
Montana
USA
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"A concrete understanding of the mechanisms that regulate tumor angiogenesis has led to advances in the clinic; however multiple challenges remain. First, not all tumors or tumor types respond equally well to anti-VEGF therapy. And for those that do, many, if not all, eventually become refractory to anti-VEGF therapies. It is essential to understand the various factors that lead to the development and function of the neovascular network in tumors in order to improve therapies and identify predictive markers. In addition, understanding basic mechanisms of angiogenesis will lead to insights into other diseases where neovascularization is an important factor in the progression or resolution of the pathology. This symposium will provide a forum to discuss the current status of anti-angiogenic therapy, new insights into the molecular and morphologic abnormalities of the tumor vascular network, methods to investigate mechanisms of angiogenesis, the relationship of the tumor microenvironment to vascular and tumor stem cells, and elucidation of recently discovered mediators of angiogenesis."
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Registration Deadline: 15-Sep-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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Mobilizing Cellular Immunity for Cancer Therapy
11-Jan-2009 -
16-Jan-2009
Snowbird
Utah
USA
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"Studies demonstrating the role of the immune system in the development and/or prevention of cancer, and elucidating the obstacles limiting an effective immune response to progressing tumors, have suggested strategies for manipulating the immune system to promote eradication of established tumors. This meeting will bring together investigators probing innate and adaptive immune systems, as well as regulatory pathways, to provide a context for developing effective tumor immunotherapies. The major objectives will be as follows: (1) explore the dual roles that components of the immune system can play early in developing malignancies, leading to protection or tumor promotion; (2) examine the mechanisms by which immune responses can be subverted by the malignant process; (3) describe the rationale for and potential benefit of immunotherapeutic strategies currently being explored for modulating adaptive immunity to achieve therapeutic anti-tumor responses; and (4) discuss the rationale for concurrently employing multiple immunosupportive modalities to enhance immunotherapeutic strategies."
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Registration Deadline: 16-Sep-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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"Innate, Adaptive and Regularotry Immune Responses to Intestinal Microbiota"
13-Jan-2009 -
18-Jan-2009
Taos
New Mexico
USA
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"Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the pathophysiology of chronic intestinal inflammation such as Crohn’s disease, ulcerative colitis and pouchitis and emphasize innate and adaptive immunoregulatory mechanisms that mediate mucosal homeostasis in a hostile environment. Major unresolved issues in mucosal immunology are as follows: (1) understanding how epithelial cells coexist with commensal intestinal bacteria, yet recognize the pathogenic organisms; (2) understanding how effector mechanisms in innate immune cells and T cells are appropriately downregulated; and (3) how understanding of basic immune regulation and inflammation can lead to the development of novel therapeutic agents for chronic inflammatory bowel diseases. This meeting presents state of the art lectures on the most recent research on innate, adaptive and regulatory immune responses to commensal bacteria, promotes interdisciplinary research interactions and explores several novel therapeutic approaches derived from recent pathogenic insights. "
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Registration Deadline: 18-Sep-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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Mechanotransduction in Physiology and Disease
18-Jan-2009 -
23-Jan-2009
Taos
New Mexico
USA
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"Cellular responses to physical forces drive morphogenesis, regulate normal physiology, and contribute to pathogenesis of atherosclerosis, hypertension, cancer, osteoporosis and deafness among others. There has been considerable progress in recent years toward identifying molecules involved in mechanotransduction, including ion channels, cell adhesion receptors, cytoskeletal and extracellular matrix molecules. Progress has also been made toward measuring and defining in vivo forces, understanding cellular effects of forces, and understanding their roles in pathogenesis. However, much remains to be learned about molecular mechanisms of transduction and transmission, and the biological consequences. Additionally, limited communication between biologists, biophysicists, engineers and clinicians/translational researchers has slowed progress. The goals of this meeting are therefore: (1) to present major, recent advances in mechanotransduction; and (2) to foster multidisciplinary interactions. The meeting will address major mechanistic questions in the context of relevant clinical problems, integrating engineering/biophysics, cell biology, and physiology/disease into each session whenever possible."
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Registration Deadline: 23-Sep-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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Allergy and Asthma
20-Jan-2009 -
25-Jan-2009
keystone
Colorado
USA
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"Allergic diseases, including asthma, affect up to one third of individuals in the developed world at some time in their lifetime, causing severe loss in the quality of life and a significant healthcare burden. Current treatments are predominantly palliative and there remains an unmet need for improved and novel treatments that provide long-term relief from disease symptoms. At this meeting, clinicians and scientists from both academic and pharmaceutical research environments will discuss: (1) risk factors for disease; (2) innate mechanisms and structural cells involved in the initiation, development and manifestations of disease; (3) effector and regulatory immune mechanisms involved in the allergic process; (4) the relationship between inflammation and structural remodeling in asthma; (5) the improvement of conventional treatments; and (6) novel emerging therapeutic strategies for the control of allergic and asthmatic disease. Opportunities for interdisciplinary interactions will be further enhanced by the concurrent meeting “Fibrosis”, which will share a session with this meeting. "
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Registration Deadline: 22-Sep-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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Multiple Sclerosis
21-Jan-2009 -
26-Jan-2009
Santa Fe
New Mexico
USA
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"Despite important recent progress, the etiology of Multiple Sclerosis (MS) remains unknown and important therapeutic needs are unmet. This conference will discuss advances in basic pathogenetic mechanisms and emergent therapies for MS. Emphasis will be on the immunopathogenesis of MS, including mechanisms of lymphocyte activation and trafficking across the blood brain barrier, on sources of axonal pathology, and genetic risk factors. New imaging methods and therapeutic strategies that target the immune system and promote remyelination will be discussed. An important challenge in MS research is to integrate emerging insights in the basic mechanisms of myelination, autoimmune demyelination, and neurodegeneration with translational science. The goal of this meeting is to provide a broad spectrum of MS researchers with a forum to discuss recent advances, and to foster cross-disciplinary interactions and collaborations."
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Registration Deadline: 24-Sep-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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Emerging Tumor Supressors
25-Jan-2009 -
30-Jan-2009
Taos
New Mexico
USA
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"This symposium will cover the recent exciting discoveries on tumor suppressors and related areas. The sessions, topics, and speakers have been chosen to reflect the fact that cancers arise from multiple defects in tumor suppressor pathways/networks. The pathways to be discussed at the meeting are among those most commonly altered in cancer cells, and where exciting results have emerged over the past few years and where considerable progress is expected. The talks will offer exciting new results from the speakers’ laboratories and it is expected that common biological themes will emerge in many sessions, such as the pleiotropic effects of tumor suppressor gene defects on multiple different cell phenotypes, and the likely cross-talk between tumor suppressor gene pathways that currently appear to be functionally distinct. "
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Registration Deadline: 25-Nov-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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Pathogenesis and Immune Regulation in Helminth Infections
01-Feb-2009 -
05-Feb-2009
Tahoe City
California
USA
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"The immunology of parasitic helminths is now attracting intense interest, due to the exciting and intricate relationship between immunity and pathogenesis, the proposed significance of regulatory immune controls in modulating both infection and disease, including allergies and autoimmunity, and the application of new molecular tools to the field situation. Currently, research aims to trace how helminths manipulate host immune cell populations, identify molecular mediators and receptor pathways involved in the host-pathogen dialogue, and design new interventions for control of infection in both human and animal contexts. This meeting will bring together scientists from many different countries (particularly those highly prevalent for helminth diseases), bridging from reductionist model systems, which offer proof of principle, to the epidemiological scale in which major insights are gained from natural infection settings. New questions from field and laboratory research will be generated, promoting the integration of different strands of inquiry and paving the way for new strategies for disease control. "
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Registration Deadline: 30-Oct-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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TH17 Cells in Health and Disease
05-Feb-2009 -
10-Feb-2009
Vancouver
British Co
Canada
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"T lymphocytes are important mediators of autoimmune diseases and their tolerance to self-antigens is tightly regulated. Regulatory T (Treg) cells maintain immune tolerance. Recently, a novel subset of CD4+ T cells that produce IL-17 (named Th17) has been identified and shown to be highly pathogenic in many autoimmune diseases. Surprisingly, there appears to be a reciprocal relationship between Th17 and Treg cells in their generation, and function. Therefore, T cell biology needs to be further re-examined in the context of molecular pathways that are required for their generation, mechanisms that are involved in their antagonism and function. The goal of this symposium is to bring the leaders in the field together to assess the increased complexity in the generation of pathogenic and regulatory T cells at the cellular, molecular and organismal levels and discuss the potential impact of these new findings on the development of treatments of human autoimmune diseases. "
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Registration Deadline: 06-Oct-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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Immunologic Memory and Host Defense
08-Feb-2009 -
13-Feb-2009
keystone
Colorado
USA
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"Immune memory has a critical role in mediating protection against infections as well as potentiating certain allergic and autoimmune diseases. Hence a thorough understanding of the cellular and molecular mechanisms regulating adaptive immune memory will have important clinical application. In this regard, there has been great progress in understanding how the innate immune response influences adaptive immunity. Furthermore, improved methods to visualize immune responses in vivo, characterize the phenotypic and functional properties of adaptive immune responses and how lymphoid and non-lymphoid compartments influence the maintenance of such responses has substantially improved our understanding in this area. However, major hurdles still relate to difficulties in eliciting sustained T cell responses sufficient to mediate protection in humans with current vaccines. The goal of the meeting will be to focus on basic mechanisms for how T and B cells are programmed to induce and sustain immunity. The program is designed to integrate information from mouse, non-human primate and human studies to encompass all relevant areas related to control of memory T and B cell responses. In summary, this meeting should facilitate translational research that will impact vaccines and interventions for infectious disease, cancer and autoimmune/allergic disease. "
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Registration Deadline: 08-Oct-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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Frontiers of NMR in Biology
15-Feb-2009 -
20-Feb-2009
Santa Fe
New Mexico
USA
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"Over the past several decades Nuclear Magnetic Resonance (NMR) spectroscopy has become an indispensable tool in structural and molecular biology, with most recent contributions to genomics, proteomics and metabolomics. Advances in NMR technology would not be possible without our continued efforts to develop new methodologies and applications. This symposium will focus on the latest technological advances in NMR spectroscopy as well as recent biological discoveries made through NMR studies. Emphasis will be placed on the investigation of large biological systems, membrane proteins, folding and dynamics, and transient states of enzymatic reactions or protein interactions. As such, those using NMR have been extending its application to more complex and challenging systems in combination with other biophysical tools such as X-ray crystallography and electron microscopy. The purpose of this symposium is to provide a forum for discussion on these and other new trends in biological NMR. "
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Registration Deadline: 15-Oct-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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Neurodegenerative Diseases: New Molecular Me
17-Feb-2009 -
22-Feb-2009
keystone
Colorado
USA
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"There have been significant advances in our understanding of the causes and pathologic progression of neurodegenerative diseases. Identification of disease-causing mutations has provided unprecedented opportunities to develop new and predictive models and move closer to new therapeutic treatments. Technological advances in biochemistry, genomics, proteomics and imaging have facilitated the ability to pose and answer complex questions in complex disease, as well as an appreciation that neurodegenerative diseases have distinct cell death signaling cascades that can share some common molecular events. In this meeting an emphasis will be placed on understanding mechanisms that may be common and those that are distinct in neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), triple repeat diseases, amyotrophic lateral sclerosis (ALS) and others. "
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Registration Deadline: 17-Oct-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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Axonal Connections: Molecular Cues for Development and Regeneration
17-Feb-2009 -
22-Feb-2009
keystone
Colorado
USA
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"The functioning of the nervous system depends on formation of a complex pattern of connections during development. If these connections are subsequently lost through injury or degeneration, axons in the adult CNS fail to regenerate, creating a major clinical challenge. The last several years have seen tremendous progress in identifying molecular mechanisms for axon development and regeneration, although much remains to be learned about these complex processes. Rapid progress is being made in identifying new classes of extracellular regulators, understanding the mechanisms by which this extracellular information is transduced by the neuron into appropriate responses, and learning the underlying molecular logic for the formation of neural connectivity. This meeting will bring together researchers in the fields of axon development, degeneration and regeneration. The meeting will promote exchange of ideas, information and collaboration among these fields, and will train young scientists in the questions, approaches, and opportunities in these exciting and topical research areas. It will also promote scientific and translational goals of understanding the basic mechanisms for the formation of neural circuits, and developing new strategies for therapeutic repair. "
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Registration Deadline: 17-Oct-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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Imaging and Drug Development
22-Feb-2009 -
24-Feb-2009
Copper Mountain
Colorado
USA
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"Positron Emission Tomography (PET) is maturing into a key scientific tool, which is increasingly applied in the scientific community and pharmaceutical industry to study drug distribution, drug-target interactions, and disease processes, especially in CNS and oncology areas. Using specific radiotracers, PET can be performed serially over time in the same live subject to study receptor occupancy and pharmacodynamic response of drug action. These studies can facilitate the selection of drug candidates to advance to clinical trials and guide clinical dose selection. This non-invasive technology also allows longitudinal studies to elucidate the underlying pathophysiology of disease, follow the progression, and monitor the outcome of treatment. The combination of genomic knowledge with PET imaging will provide more specific phenotypes that can help to identify genetic predictors of drug response. The objective of this conference is to bring together a wide range of academic and industrial scientists within the PET molecular imaging community with expertise in imaging systems, analytical tools, and drug discovery/development to address some key issues common to the fields of neurology and oncology. The meeting will provide a forum for the cross-fertilization of experience across these two disciplines, including sharing of knowledge in the development and usage of radiotracers, identifying gaps and opportunities in using PET to facilitate drug development, and discussing innovative solutions to overcome challenges in multi-center trials and biomarker qualification/validation. "
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Registration Deadline: 21-Oct-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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Drug Discovery for Protozoan Parasites (D2)
22-Mar-2009 -
26-Mar-2009
Breckenridge
Colorado
USA
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"The discovery and development of new drugs for protozoan parasites has rapidly expanded to include multidisciplinary approaches from academia, government, and industry. Public-private partnerships have focused efforts on translational research and as a result, new drugs have been advanced into clinical evaluation. Unfortunately, development of several promising new drugs has recently been terminated in clinical trials thus leaving a sparse pipeline of new chemical entities that have potential for registration in the next few years. Importantly, the need for effective new drugs for major human parasitic diseases (malaria, leishmaniasis, and trypanosomiasis) is growing and concerns over antimalarial resistance to artemisinin-based drugs are building. This meeting will bring together chemists, biologists, pharmacologists, and clinicians to find solutions to accelerate drug discovery efforts. Key problems to be addressed include identification and validation of new targets, chemical biology and medicinal chemistry approaches to characterize new compounds, novel screening techniques to identify new chemotypes, mechanisms of drug resistance, and cutting edge strategies to progress new drug candidates into clinical trials. The objectives of this meeting are to discuss current methods to identify and validate new drug targets and to screen libraries of compounds to discover novel chemotypes; assess the potential for chemical biology and medicinal chemistry to optimize compounds that are specific and avoid resistance mechanisms; and identify critical paths for compound progression and to discuss the utility of key models for assessing preclinical drug leads. "
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Registration Deadline: 24-Nov-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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Antibodies as Drugs (X7)
27-Mar-2009 -
01-Apr-2009
Whistler
British Co
USA
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"Despite being theorized more than 100 years ago as the “magic bullets” to treat a range of diseases, it is only within the last 10 years that antibodies have become an important class of therapeutics. This meeting will bring together experts from academia and industry to discuss the current state of antibody therapeutics, their mechanism of action in a range of medical indications, novel approaches to improving discovery, manufacturing, formulation, and pharmacokinetics, methods to predict and increase therapeutic efficacy, as well as novel therapeutic opportunities in cancer, infectious diseases, allergy, inflammatory diseases, and the neurosciences. This meeting will be of interest to academic and industry scientists working in all these fields. "
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Registration Deadline: 01-Dec-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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Pattern Recognition Molecules and Immune Sensors of Pathogens (Z1)
29-Mar-2009 -
03-Apr-2009
Banff
Alberta
Canada
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"The discovery of evolutionarily conserved immune genes and pathways has led to an explosive discovery phase in innate immunity. These pathways include TLR, NLR, C-type lectin Receptor, and the helicase-containing anti-viral proteins. These novel pathways merge the innate and adaptive branches of immunity, and converge on a wide range of disorders including infectious diseases, inflammation and autoimmunity. All of the above have systemic effects that can affect the outcome of a wide range of diseases ranging from cancer to cardiovascular disorders. "
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Registration Deadline: 02-Dec-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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Common Mechanisms in Arrhythmias and Heart Failure (D3)
02-Apr-2009 -
07-Apr-2009
Keystone
Colorado
USA
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"Electrical and mechanical disturbances in heart function underlie most cardiovascular morbidity and mortality. Investigations into the causes of cardiac arrhythmias and heart failure have led to considerable improvements in diagnosis and treatment of these conditions. Recent advances uncovering the molecular genetic basis for familial cardiomyopathy and inherited arrhythmia susceptibility have fueled greater interest in defining common pathophysiological mechanisms. This Keystone Symposia meeting will bring together experts in both fields to exchange ideas and explore common areas of interest. Major areas of emphasis for the symposium will include genetic mechanisms, electrical and transcriptional remodeling, regulation and disorders of cardiac ion homeostasis, and the complex interplay between molecules governing electrical and contractile events in the heart. The goal of this meeting is to stimulate new areas of investigation at the interface between the biology of heart rhythm and contraction, ideally leading to new therapeutic strategies and targets."
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Registration Deadline: 03-Dec-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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The Future of Biofuels (D4)
04-Apr-2009 -
08-Apr-2009
Snowbird
Utah
USA
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The goal of this meeting is to share a broad perspective defining the critical needs for biofuels and to highlight cutting edge research and development efforts that are defining the next generation of biofuel product and process advances. One major deficiency in the advancement of biofuels is the need to do more integrated and cross-disciplinary research. This conference brings together a broad spectrum of core experts to bridge this gap and help to better enable and advance biofuel research efforts globally.
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Registration Deadline: 03-Dec-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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Stem Cell Niche Interactions (D5)
21-Apr-2009 -
26-Apr-2009
Whistler
British Co
USA
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"Embryonic stem cells are pluripotent precursors able to differentiate into the many cell types of the body. Adult or tissue stem cells are undifferentiated but lineage specific precursor cells able to proliferate long term while producing daughters that maintain the undifferentiated state (self-renew) and daughters that differentiate into specific cell types. In addition to their intrinsic interest for developmental biology, both kinds of stem cells have great promise for tissue renewal and regenerative medicine. Much has been learned in the past year about the mechanisms that maintain and induce stem cell pluripotency, the mechanisms that control differentiation, and the molecular regulation of stemness and self-renewal. Interactions between stem cells and their niches regulate self-renewal versus differentiation of adult stem cells and key signals from surrounding cells may organize fate decisions in space and time to pattern early embryonic development and differentiation of specific cell types. Understanding of the fundamental biology of embryonic and adult stem cells is being translated into development of “artificial niches” and conditions for controlling cell proliferation and differentiation. This meeting will bring together stem cell scientists from diverse model systems and backgrounds. All career levels will be represented. Current opportunities and challenges in the field will be highlighted in an atmosphere of informal exchange, facilitating new ideas and collaborations towards meeting the next great challenges in the field."
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Registration Deadline: 22-Dec-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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PI 3-Kinase Signaling in Disease (Z3)
22-Apr-2009 -
27-Apr-2009
Olympic Valley
California
USA
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"The PI 3-kinase signaling pathway controls multiple physiological processes including cell growth, cell proliferation and cell movement. Dysregulation of this pathway in cancer, inflammation and heart disease has led to the emergence of PI 3-kinase as a promising therapeutic target. One of the most exciting developments in this field is the discovery of new PI 3-kinase inhibitors. The balance between modulating PI 3-kinase activity in pathophysiological setting, whilst avoiding unwanted side-effects, is the subject of intense debate. In addition, as PI 3-kinase is a member of a multigene family, the rationale for inhibiting individual isoforms or multiple isoforms of PI 3-kinase is constantly changing. This meeting aims to bring together scientists and clinicians from academia and industry to discuss the opportunities and liabilities of targeting the PI 3-kinase pathway in disease, drawing on human pathophysiology and genetics, mouse models and preclinical data with new PI 3-kinase inhibitors."
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Registration Deadline: 23-Dec-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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The Biology of RNA Silencing (D6)
25-Apr-2009 -
30-Apr-2009
Victoria
British Co
USA
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"During the past decade, a set of pathways collectively known as “RNA silencing” has been shown to use small RNA molecules to regulate gene expression and protect cells from pathogens. RNA silencing pathways control an ever-expanding range of biological phenomena, and defects in these pathways lead directly to disease. In addition, small RNAs hold great promise as therapeutic agents. The physiological mechanisms of RNA silencing are only partially understood. Furthermore, small RNAs are known to affect gene expression at many different levels, but the ways in which these different levels of silencing are integrated remain obscure. Our ability to harness RNA silencing for therapeutic purposes depends critically on our knowledge of the underlying biology. The goals of this meeting are to bring together leading researchers working on different branches of RNA silencing to share their findings and facilitate a deeper understanding of the breadth and complexity of small RNA-related phenomena."
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Registration Deadline: 29-Dec-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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Human Immunology and Immunodeficiencies (D7)
12-May-2009 -
17-May-2009
Beijing
China
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"The study of human immunodeficiency, whether inherited or acquired, is an outstanding and illuminating approach for the understanding of human immunology. The clinical investigation of these experiments of nature provide novel insights into the physiology of immune responses. In the course of this Keystone Symposia meeting we aim to bring together experts in the three related fields of primary immunodeficiencies, complex genetics of infectious diseases, and virus-induced immunodeficiency. The immunological and clinical lessons learned from the care and investigation of patients with these conditions will be discussed. "
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Registration Deadline: 12-Jan-2009
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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"Protein Dynamics, Allostery and Function (E3)"
05-Jun-2009 -
10-Jun-2009
Keystone
Colorado
USA
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"With recent progress in exploring biomolecular systems dynamics, an emerging view is that of the ‘intrinsic ability’ of biomolecular systems to populate an ensemble of fluctuating conformations, or alternative states, which include, in particular, the functional forms stabilized upon ligand/substrate binding or protein-protein interactions. Allosteric changes in conformations, or signal transduction mechanisms, thus emerge as properties encoded by the structure and energy landscape, which are evolutionarily selected due to their functional predisposition. Of particular interest is to elucidate the mechanisms of information flow, not only at the level of residue interactions, but also between the components of biomolecular machines or cell signaling networks. This Keystone Symposia meeting will provide a forum for researchers from diverse fields to explore the basic principles underlying allosteric responses at the molecular level, and their higher (cellular) level consequences, and to exchange expertise on methods to illuminate key dynamic properties of biomolecular systems. "
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Registration Deadline: 05-Feb-2009
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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MicroRNA and Cancer (E1)
10-Jun-2009 -
15-Jun-2009
Keystone
Colorado
USA
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"MicroRNAs have recently emerged as key regulators of gene expression during development and are frequently mis-expressed in human disease states, in particular cancer. MicroRNAs act to promote or repress cell proliferation, migration and apoptosis during development, all processes that can go awry in cancer. Thus, microRNAs have the ability to behave like oncogenes or tumor suppressors. Their small size and molecular properties make miRNAs amenable as targets and therapeutics in cancer treatment. While hundreds of human microRNAs are known, relatively little is known about their roles and targets. This meeting will focus on the exciting biology of microRNAs in controlling developmental and cancer processes like cell proliferation, differentiation, cell cycle, apoptosis and metastasis. It will also focus on the latest efforts to harness the power of these small RNAs as agents in the fight against cancer. "
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Registration Deadline: 10-Feb-2009
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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The Many Faces of Ubiquitin
11-Jan-2009 -
16-Jan-2009
Copper Mountain
Colorado
USA
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"The ubiquitin (Ub) pathway controls many biological processes and determines how cells respond to growth factors, stress and genetic damage, controlling nearly every facet of a cell’s life and death. The covalent attachment of Ub to proteins can alter their localization, activities, and ultimate fate. One of the most intriguing features of the ubiquitin pathway is its emerging involvement in functions not directly related to protein degradation. In addition, some half-dozen related ubiquitin-like (Ubl) proteins, such as SUMO, are also revealing themselves as regulators of numerous cellular pathways. The existence of this vast and dynamic array of Ub and Ubl signals raises the central question of how specificity is achieved during conjugation, recognition, and signal transduction. Indeed, the molecular requirements for generating and recognizing various Ub signals are poorly understood and form a central unresolved issue in the field. This meeting will focus attention on the biology associated with Ub/Ubl-mediated signal transduction, including its role in human disease and cancer. The goal of this meeting is to gather a diverse array of scientists, not just “ubiquitinologists”, but also biologists whose work has been touched in some way by ubiquitin or ubiquitin-like pathways. By bringing together scientists from different backgrounds who work on a wide range of systems that are regulated by Ub and Ubl conjugation, this meeting will create a fertile ground for exchange of ideas on non-conventional functions for Ub and Ubl proteins in signal transduction. "
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Registration Deadline: 16-Sep-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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"Plant Sensing, Response and Adaptation to the Environment "
11-Jan-2009 -
16-Jan-2009
Big Sky
Montana
USA
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"Understanding plant environmental responses requires not only considering the structural biology and molecular mechanisms of signal transduction from photoreceptor proteins, but also ecological and evolutionary genetic approaches to adaptation. Progress is being made in how circadian clocks are used to integrate daily light and temperature changes into seasonal information to control daily as well as seasonal reproductive growth. However integrating these multidisciplinary approaches into a community effort remains a challenge. Often the photoreceptor biochemist is not aware of approaches that use sequence diversity to capture population information, and vice versa. There is also a separation in the field between those studying different sensory pathways: e.g. light, temperature and pathogen presence. This meeting aims to bring these scientists together by transcending biochemistry and population genetics approaches to understanding plant sensing and environmental adaptation. The meeting will promote interaction between these fields and advance our understanding through collaborations. "
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Registration Deadline: 16-Sep-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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Fibrosis
20-Jan-2009 -
25-Jan-2009
keystone
Colorado
USA
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"Fibrosis is a major cause of morbidity worldwide, can affect nearly all tissues, and is a dominant feature of diseases ranging from pulmonary fibrosis to glomerulosclerosis and cancer. Current treatments targeting the inflammatory cascade are ineffective in fibrosis. On-going research focuses on the role of innate immunity, and intrinsic mesenchymal cell alterations, plasticity, and progenitor cell differentiation in the pathogenesis. Experimental models, genetics and functional genomics have uncovered novel aspects of fibrosis, and innovative therapies are entering clinical trials. However, consensus on robust outcome measures or appropriate biomarkers for evaluating therapeutic effectiveness is lacking. This meeting brings together academic clinicians, researchers and pharmaceutical industry representatives from a variety of fields (1) to identify themes shared among the different fibrosing disorders, (2) to delineate promising novel molecular and cellular targets and treatment strategies, and (3) to discuss outcome measures and biomarkers for clinical trials. Opportunities for interdisciplinary interactions will be further enhanced by the concurrent meeting “Allergy and Asthma”, which will share a session with this meeting. "
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Registration Deadline: 22-Sep-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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Type 2 Diabetes and Insulin Resistance
20-Jan-2009 -
25-Jan-2009
Banff
Alberta
Canada
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Obesity: Novel Aspects of the regulation of Body Weight
20-Jan-2009 -
25-Jan-2009
Banff
Alberta
Canada
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"Obesity remains among the most daunting health problems facing the developed world. Despite the rising prevalence of obesity, the biological systems that serve to match caloric intake to caloric expenditure are robust and make permanent weight loss difficult to achieve. Current research points to a multitude of factors that contribute to this regulation. Identifying the processes that are most amenable for therapeutic intervention is a crucial research goal. To that end, this conference will focus on the latest work identifying novel genes, hormones and signaling cascades that regulate energy balance. The program will also emphasize a wide range of new strategies for using this new information to produce safe and effective therapies to prevent or treat obesity. "
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Registration Deadline: 22-Sep-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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Omics Meets Cell Biology
25-Jan-2009 -
30-Jan-2009
Breckenridge
Colorado
USA
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"Apart from deciphering the genomic sequences of hundreds of species, the (human) genome project has catalyzed a wave of technological innovation that is unprecedented in the life sciences. Among its most important products are a number of assays or technologies for the quantitative, global and high throughput analysis of the genome, the molecules derived from the genome and their interactions. These technologies are colloquially described as “OMICS” technologies. The data sets generated by OMICS technologies represent a unique resource for biologists. They have also raised a number of challenging technical and conceptual issues, the solutions to which will ultimately determine the impact of OMICS technologies on biology. These include the error models, completeness and reproducibility of large scale data sets, the question whether and how different data types obtained from the same systems can be integrated and, most importantly, whether validated new biological knowledge has been or will be created either from OMICS data alone or by strategies that combine OMICS and traditional approaches. This conference will bring together the leading experts representing OMICS technologies and leading cell biologists to discuss these issues."
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Registration Deadline: 25-Jan-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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"Tuberculosis: Biology, Pathology and Therapy"
25-Jan-2009 -
30-Jan-2009
keystone
Colorado
USA
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"Tuberculosis kills 2 million people per year worldwide. Although great strides have been made in the past decade in understanding Mycobacterium tuberculosis, the complexity of the disease necessitates a multi-pronged approach. Translating insights related to host-pathogen interplay and bacterial physiology into treatments is complex, requiring academics and industrial scientists to come together in new and creative ways. In humans the infection is persistent and chronic, yet reactivates into fulminating progressive disease. This, and the shortage of appropriate animal models, form major obstacles to identifying factors that determine disease progression and the extensive pathology associated with transmission. This meeting will focus on basic mechanisms of pathogenesis of Mycobacterium tuberculosis, and how the balance of control of infection within the granuloma is influenced by host and bacterial factors. We will also focus on translating basic mechanistic findings to the development of therapies, and a workshop highlighting academic-industrial partnerships is planned. "
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Registration Deadline: 29-Jan-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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Frontiers in Reproductive Biology and Regulation of Fertility
01-Feb-2009 -
05-Feb-2009
Santa Fe
New Mexico
USA
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"Sexual reproduction is a complex and highly regulated process essential for successful propagation and diversification of genetic complements, beginning with germ cell development and completing with birth of live young. For successful reproduction, a plethora of events including gametogenesis, ovulation, fertilization, implantation, and placentation requires precise regulation; the success of each go-ahead event is dependent on the accomplishment of the preceding event. Research on these events and their coordination has been translated into clinical practice, particularly for enhancing successes in fertility clinics, controlling gynecological diseases and developing contraceptives. This meeting is designed to bring together a diverse group of leaders, established and rising in the field, who study the complex regulation of reproduction and related developmental processes. The speakers and participants will comprise a group that uses a variety of model systems to better understand the processes relevant to human and animal reproduction and fertility regulation. "
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Registration Deadline: 30-Oct-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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Therapeutic Modulation of RNA Using Oligonucleotides
08-Feb-2009 -
13-Feb-2009
lake Louise
Alberta
Canada
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"The recent discoveries of the RNAi pathway in mammalian cells and the finding that oligonucleotides can activate the innate immune system through Toll-like receptors have resulted in increased interest in oligonucleotide-based therapeutics. There are two basic therapeutic approaches in which oligonucleotides are being utilized: (1) binding to RNA resulting in selective inhibition of gene expression; and (2) modulating protein function by direct binding to proteins. Although both approaches share common manufacturing, toxicology and ADME issues, oligonucleotides that are designed to bind RNA inside the cell have a fundamental different set of challenges than oligonucleotides designed to bind to proteins outside the cell. This meeting will focus on the former application. A goal of this meeting is to bring together scientists from both the basic science disciplines and applied disciplines to gain a common understanding of the attributes and challenges the technology faces. This meeting will consider basic mechanisms by which oligonucleotides can be exploited to modulate gene expression, mechanisms for distribution of oligonucleotides to tissues and within cells and how chemistry and/or formulations can improve the pharmaceutical properties of oligonucleotides. Finally recent advances in both preclinical applications and clinical results will be presented."
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Registration Deadline: 08-Oct-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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The Neurobiology of Pain and Analgesia (C2)
22-Feb-2009 -
27-Feb-2009
Santa Fe
New Mexico
USA
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"This symposium will highlight the substantial advances made in our understanding of the neurobiology and pathophysiology of pain and the enormous opportunities these present for identifying and exploiting new targets for therapy. Current therapy is largely empirical and is based on suppressing symptoms. The future offers treatment targeted at the specific neural mechanisms responsible. This requires understanding the mechanisms, being able to identify which mechanism operates in which patient, and having pharmacological tools to act on the molecular targets that drive these mechanisms. Furthermore, we need to identify which patient is at risk of developing pain and develop preventative disease-modifying treatments to abort the establishment of pain. This symposium will address how these goals can be achieved by the combined effort of academics and industry. "
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Registration Deadline: 21-Oct-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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Complications of Diabetes and Obesity (J7)
24-Feb-2009 -
01-Mar-2009
Vancouver
British Co
USA
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"The complications of diabetes and obesity are emerging as major health problems in the United States and world-wide. Obesity-linked complications may lead to the development of insulin resistance and, ultimately, hyperglycemia. Thus, the study of mechanisms underlying and linking these disorders holds promise for the identification of mechanism-targeted therapeutic agents. In addition to frank and often destructive recruitment of immune responses, diabetes and obesity are significantly modified by host and environment factors. Such factors as hypertension, innate aging, failure of effective pro- or anti- angiogenesis programs, genetic and epigenetic factors may influence the phenotype and outcome in diabetes and obesity. The goals of the meeting will be to integrate these concepts in close collaboration with the “Dissecting the Vasculature” concurrent meeting group. Beginning with the vessel, and addressing superimposed and modifying factors, this program will facilitate greater understanding of mechanisms linked to diabetes and its complications and obesity."
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Registration Deadline: 23-Oct-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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"Dissecting the Vasculature: Function, Molecular Mechanisms and Malfunction (J8)"
24-Feb-2009 -
01-Mar-2009
Vancouver
British Co
USA
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"The goal of this meeting is to present the most current research on the vasculature by breaking down the blood vessel into individual cells (endothelium, smooth muscle and nerve) and examine the function of organelles (nucleus, ER, plasma membrane) within each cell type. This work will be synthesized into the whole blood vessel, and a focus given to vessel dysfunction in hypertension and—as is highlighted by a concurrent meeting—diabetes. Workshops will support young investigators, and techniques specific to studying the vasculature. Attendees should take away an appreciation for the complexity and beauty of the vasculature."
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Registration Deadline: 23-Oct-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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Genome Instability and DNA Repair (C6)
01-Mar-2009 -
06-Mar-2009
Taos
New Mexico
USA
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"DNA damage repair and the DNA damage response overall are critical to the organism for both tumor suppression and the propagation of genomic information to subsequent generations. Tremendous advances have occurred in the last several years which have enlightened our understanding of the DNA damage response in all organisms and the derivation of genomic rearrangements, including in mouse and human. This meeting will highlight recent advances. Programmed DNA damage and its repair will be presented in sessions on the immune system and meiosis and germ cell development. Mechanisms of DNA repair will be presented in sessions on homologous recombination and non-homologous end-joining. Genomic rearrangements arising from sequence repeats and repetitive elements will also be presented."
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Registration Deadline: 04-Nov-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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Epigenetic Basis of Neurodevelopmental Disorders (X2)
06-Mar-2009 -
10-Mar-2009
Keystone
Colorado
USA
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"Neurodevelopmental disorders are highly heterogeneous constellations of disorders, both in terms of etiology and clinical manifestations. Past effort has focused on identifying the genetic basis of these disorders with minimal success. Epigenetic modulations, mediated by DNA methylation, RNA-associated silencing, and histone modification, can imprint dynamic environmental experiences on the “fixed” genome, resulting in stable alterations in phenotypes. This conference will focus on an emerging area of biomedical research: how epigenetic modulation shapes brain development and disorders. The meeting will examine the common molecular pathways affected in several related neurodevelopmental disorders and discuss how pre- and postnatal exposures to pollutants, alcohol, drug, nutrition, and parental care, etc., may affect neurodevelopment via epigenetic pathways. The overall goal of the meeting is to gain insight into the common molecular pathways affected among these disorders and to discover potential therapeutic targets that have been missed by looking at one disorder at a time. "
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Registration Deadline: 06-Nov-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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Extrinsic Control of Tumor Genesis and Progression (C8)
15-Mar-2009 -
20-Mar-2009
Vancouver
British Co
USA
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"It has long been known that the interactions between cells and their respective microenvironments are instructive and necessary in proper development. Cell-environment interactions play complex roles in organ homeostasis and, when altered, disease. Increasing evidence now suggests that the microenvironment also modulates critical aspects of the genesis and progression of tumors. For example, initiation, progression and even control of metastasis and latency are governed by these interactions. This modulation is most likely brought about through both genetic and epigenetic mechanisms. Currently, the signaling pathways and mechanisms of regulation are mostly unknown. This conference will bring together leaders in this field to discuss current problems and strategize on the clinical application of new insights."
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Registration Deadline: 17-Nov-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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"Cardiac Disease: Development, Regeneration and Repair (D1)"
15-Mar-2009 -
20-Mar-2009
Asheville
NC
USA
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"Cardiac muscle death, without numerically equivalent myocyte creation, poses a formidable and inexorable challenge in both acute and chronic forms of heart disease. A regenerative medicine approach to rescue cardiac muscle cell number or instigate heart repair in other ways has moved from the esoteric fringe to the mainstream of both fundamental and patient-based cardiovascular research. However, notwithstanding the encouraging results from phase I and even phase II trials in this realm, the scientific foundations of cardiac repair largely remain to be proven on a basis that is more than empirical. By virtue of its orientation not merely to translation, but at least equally to the enabling sciences within stem cell biology, cardiovascular development, and genetics, this Keystone Symposia meeting addresses a critical unmet need in a high-impact field of current and foreseeable explosive growth. "
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Registration Deadline: 18-Nov-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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Prevention of HIV/AIDS (X3)
22-Mar-2009 -
27-Mar-2009
Keystone
Colorado
USA
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"Most recent research efforts on the prevention of HIV and AIDS has focused on T cell-based vaccines but it is admitted this approach will not prevent HIV and needs to be strengthened by novel approaches to generate HIV neutralizing antibodies. The recent successes or failures of alternative methods of HIV prevention (e.g., microbicides, circumcision), or of AIDS prevention (therapeutic vaccines) should help better understand how HIV vaccines can be used, and require sharing basic understanding and results with the prophylactic vaccine field. However the recent negative results of a major HIV vaccine trial have substantially disorganized the field and limit preparation of a definitive program a year and a half in advance. The goals of the meeting are therefore to focus on the most recent key advances in the understanding of (1) how HIV can be controlled at entry and after infection in 3 joint sessions with the concurrent “HIV Immunobiology” meeting, (2) how T cell-based or antibody-based HIV vaccines can be improved, and (3) what are the results of the current vaccine trials and those of alternative methods of HIV or AIDS prevention and how can they help at re-orientating vaccine researches. Two workshops will provide key information on the definition of immune correlates of protection and their analysis in clinical trials."
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Registration Deadline: 24-Nov-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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HIV Immunobiology: From Infection to Immune Control (X4)
22-Mar-2009 -
27-Mar-2009
Keystone
Colorado
USA
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"This meeting will highlight the latest breakthroughs in basic HIV research, ranging from the molecular bases of HIV replication to the host genetic determinants influencing viral spread and disease susceptibility; and from the intricacy of the interaction between HIV and the immune system to the most promising progress in therapeutic development. The meeting will identify new levels of possible intervention to control the progression of HIV-induced disease and, more generally, deepen our understanding of the intimate interaction between retroelements and human hosts. Dynamism will be ensured by having concise, up-to-date talks rather than lengthy lectures, by giving ample room to speakers chosen from the abstracts, and by a close coordination with the concurrent meeting on ""Prevention of HIV/AIDS"". Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting, which will share a keynote address and three plenary sessions with this meeting."
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Registration Deadline: 24-Nov-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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Cell Death Pathways (X5)
22-Mar-2009 -
27-Mar-2009
Whistler
British Co
USA
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"Programmed cell death plays a critical role during development and adult homeostasis by eliminating unneeded and damaged cells, and defects in cell death can result in a wide range of diseases. While studies of apoptotic cell death have defined central regulatory mechanisms including a role for mitochondria, the relationship between core apoptosis factors, mitochondrial physiology, and how this relates to normal and aberrant development remains unsolved. The purpose of this meeting is to define the relationship between mitochondria and cell death pathways. The meeting will focus on the relationship between apoptosis regulatory pathways, mitochondrial physiology, metabolism, and non-apoptotic death mechanisms in the context of normal development and pathological situations including degenerative disorders and cancer. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting “Mitochondrial Dynamics and Physiology”, which will share a keynote address and two plenary sessions with this meeting. "
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Registration Deadline: 25-Nov-2008
http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?Meetin
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