Dr. Greenwald's lab studies how cell-cell signaling can specify cell fate during development. They utilize the differentiation of pluripotent C. elegans vulval precursor cells (VPCs) to specific cell fates as a model. This rich system includes LIN-12/Notch, a receptor tyrosine kinase (RTK) / Ras / mitogen-activated protein (MAP) kinase cascade, its proteolytic cleavage by a Delta / Serrate / LAG-2 ligand, wnt signaling, and microRNA-mediated gene regulation. [More...]
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