Dr. Kenyon's lab is focused on a molecular genetic dissection of aging vs. longevity, using C. elegans. The lab discovered that the worm homolog of the human insulin / IGF-1 receptor (DAF-2), and the FOXO-family transcription factor DAF-16, coordinately regulate lifespan transcriptionally and hormonally. Their parallel studies show that the heat-shock, reproductive, mitochondrial and sensory systems each contribute to aging. [More...]
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