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Heart Failure: Genetics, Genomics and Epigenetics (Z1)

03-Apr-2016 - 07-Apr-2016
Snowbird UT USA

Heart failure (HF) is a worldwide epidemic with treatments costing tens of billions of dollars every year. Despite this investment, HF therapies have limited efficacy in reducing disease progression. Recent insights in fundamental myocyte biology, HF etiologies and pathogenic mechanisms are propelling new strategies to treat and prevent HF. This meeting will explore biologic and technical advances that inform the genetic architecture, molecular pathogenesis and innovative approaches to treat HF. This comes at a time when very large human HF datasets are available and can be interrogated using advanced computational and bioinformatic approaches. Specific aims are to: 1) Consider genes, molecules, signaling pathways and biomarkers involved in systolic and diastolic HF in humans; 2) Explore disease mechanisms underlying HF in model systems; 3) Understand the role of epigenetics, miRNAs and lncRNAs in HF pathogenesis; and 4) Review translational programs in genomic, pharmacologic and cell-based therapeutics to treat HF. The outcomes of this meeting should be far-reaching for basic, translational and clinical communities. The meeting should also provide an excellent training program for junior scientists and serve as a catalyst for collaboration among research, clinical and industrial participants. This meeting is being held in conjunction with the �Cardiac Development, Regeneration and Repair� meeting that provides an outstanding opportunity for joint sessions in genetics, iPSC disease modeling, stem cell therapeutics and epigenetics.

Registration Deadline: 04-Feb-2016
http://www.keystonesymposia.org/index.cfm?e=web.Meeting.Program&meetingid=1378

Cardiac Development, Regeneration and Repair (Z2)

03-Apr-2016 - 07-Apr-2016
Snowbird UT USA

Cardiovascular disease is the leading cause of death worldwide. There is increasing evidence that developmental mechanisms regulating cardiac and vascular cell lineage differentiation and organogenesis contribute to cardiovascular disease in childhood and throughout life and could be leveraged to reduce cardiac damage and mediate repair or regeneration once damage has occurred. This meeting will emphasize shared molecular mechanisms in cardiovascular development, regeneration and disease and consider how patient-relevant pluripotent stem cell models can contribute to understanding human disease states. Discussion of new bioassays, methods of genetic modification and bioengineering in animals and stem cells will complement these sessions, with the aim of facilitating translational approaches in cardiovascular regeneration, repair and disease modeling. Specific aims are to: 1) Consider animal models for understanding cardiovascular cell lineage commitment, differentiation and proliferation; 2) Explore how this can be applied to creating new stem cell-based models that result in mature cardiovascular derivatives and assays for disease target discovery; and 3) Explore therapeutic potential for cardiovascular repair and regeneration mechanisms in clinical practice. Overall, the goal of the meeting is to bring together world-class speakers and researchers with expertise in cardiac embryology, molecular biology, stem cell biology, human genetics and tissue engineering to facilitate new scientific directions and therapeutic approaches in the management and treatment of cardiovascular disease.

Registration Deadline: 04-Feb-2016
http://www.keystonesymposia.org/index.cfm?e=web.Meeting.Program&meetingid=1379

Positive-Strand RNA Viruses (N1)

01-May-2016 - 05-May-2016
Austin TX USA

Positive-stranded RNA viruses are significant and emerging human pathogens worldwide. Virus-host interactions and innate responses by the host are intensively studied areas, which promise novel, broad-range and durable antiviral approaches. Topics covered by the meeting include basic advances in research on viral replication structures, virus entry and virus evolution; virus-host interactions, discussed from the virus view on changing the host (including systems biology) and host responses and defense mechanisms; and emerging therapeutics. It is anticipated that rapidly emerging new concepts on virus-host interactions will help the participants to test various host factors for a large number of positive-strand RNA viruses to expand the arsenal of antiviral approaches. This meeting will bring together experts on positive-stranded RNA viruses that will facilitate the rapid progress and dissemination of new concepts in the complex field of virus-host interactions. Also, speakers who are expert with other groups of viruses will be invited to facilitate cross-talk with other areas in virology. Among the speakers will be interdisciplinary scientists who would not normally meet with this group of researchers. Virology, cell biology, genetics, evolution, macromolecular structures/assembly, systems biology and imaging will all be brought together.

Registration Deadline: 06-Mar-2016
http://www.keystonesymposia.org/index.cfm?e=web.Meeting.Program&meetingid=1415

Nucleic Acid Sensing Pathways: Innate Immunity, Immunobiology and Therapeutics (E2)

08-May-2016 - 12-May-2016
Dresden Sachsen DE

Human cells possess intricate nucleic acid recognition processes for monitoring cellular stress and pathogen infection, which trigger the production and release of interferons and cytokines to alert neighboring cells including cells of the immune system. Various classes of nucleic acid sensors, each specific to detecting modified or unmodified, structured or unstructured DNA or RNA, have been identified and are characterized by distinct subcellular localization and also cell-type-specific expression patterns. These sensors include various nucleotidyl transferases producing second messenger small ribonucleic nucleic acid molecules as well as membrane-bound receptors ultimately leading to phosphorylation of transcription factors driving cytokine and interferon expression. This meeting focuses on cytoplasmic DNA and RNA sensors and the function of their linear and circular oligonucleotide second messenger cGAMP and 2�,5�-oligoadenylate produced upon activation. Substantial progress has been made in identification of the structures of these sensors, their nucleic acid ligands and second messenger molecules, as well as the underlying molecular pathways leading to transcriptional activation. Animal models inactivating various pathways of innate immunity have been developed. This progress has enabled targeted development of antagonists and agonists of cytokine and interferon production for therapeutic targeting of inflammatory diseases and vaccine adjuvant development, respectively. An international group of academic and industry scientists and clinicians with expertise in biochemistry and structural biology, nucleic acid chemistry, immunology, human genetics, virology, rheumatology and vaccine development will converge at this meeting to discuss the latest developments in this field.

Registration Deadline: 08-Mar-2016
http://www.keystonesymposia.org/index.cfm?e=web.Meeting.Program&meetingid=1399

Understanding the Function of Human Genome Variation (K1)

31-May-2016 - 04-Jun-2016
Uppsala Uppsala Sweden

One of the most complex problems in medical and evolutionary genomics is interpreting the function of the millions of variants the genome contains, most being rare and private to each individual or with consequences constrained to specific cells or tissues. The functional consequences of variation in coding regions are well established, but the majority of genetic variation resides in the noncoding portion of the human genome. In fact, >85% of genome-wide association signals fall outside coding regions, suggesting a large contribution from variants not well understood both to complex disease and to variation selected for different types of adaptation. The goal of this meeting is to bring together experts that may address important questions such as the function of noncoding variation, the connection between selection and disease, the diverse action of variants in different physiological and pathological scenarios, who develop and apply novel tools to connect genotype and phenotype both in disease and in an evolutionary context. By combining the diverse knowledge of many aspects of genomic analysis, we hope to bring out critical discussion and novel approaches to understanding human genome variation of crucial importance for the individualized genome analysis that precision medicine proposes. We are now entering the age of precision medicine with the capacity to analyze the genome of every subject, evaluating the functional consequences of variability and its interaction with the environment at different time-points in life. This is a new scenario for human biology and genetics in which fields need the convergence of different communities of scientists to address human complex disease, genome biology and evolutionary genomics in to a broader discussion on genome function. Our goal here is to bring together a very cross-disciplinary set of speakers that can address all aspects of genome variability and function, and thus to open everyone's eyes to the interplay between selection and disease, as well as the likely importance of pleiotropic consequences of genetic variability based on genome function and evolution.

Registration Deadline: 31-May-2016
http://www.keystonesymposia.org/index.cfm?e=web.Meeting.Program&meetingid=1393

The 66th Annual Meeting of The American Society of Human Genetics

03-Dec-2016 - 07-Dec-2016
San Francisco CA USA

The Affordable Meeting You Can't Afford To Miss. Great value that will pay off in the short and long term. See the future of cell biology. Be the future of cell biology.

Registration Deadline: 30-Apr-2016
http://www.ascb.org/future-ascb-annual-meetings/

The 21st International C. elegans Conference (GSA Worm Meeting)

21-Jun-2017 - 25-Jun-2017
Los Angeles CA USA

This is the amazing International Worm meeting where scientists meet every other year to present and discuss their research on diverse topics such as neurobiology, aging, cancer, development, and evolution centering around the model genetic organism C. elegans.

Registration Deadline: 01-May-2017
http://www.genetics-gsa.org/celegans/2017/